Gene polymorphisms of intracerebral hemorrhage in Chinese population: a systematic review / 中华神经科杂志

ABSTRACT

Objective To assess the genes polymorphisms associated with intracerebral hemorrhage (ICH) in Chinese quantitatively or qualitatively by searching all case control studies related comprehensively.Methods Odds ratio (OR) and 95％ confidence intervals (95％ CI) were determined for each polymorphism using fixed or random model with Revman 5.1.Results Statistically significant associations with ICH were detected with both ε4-carrier genotypes and ε2-carrier genotypes of apolipoprotein E (OR =1.59,95％ CI 1.23-2.04,P ＜ 0.01 and OR =1.92,95％ CI 1.50-2.47,P ＜0.01),methylenetetrahydrofolate reductase C677T (OR =2.08,95％ CI 1.52-2.83,P ＜ 0.01) and angiotensin converting enzyme insertion/deficiency (OR =2.34,95％ CI 1.82-3.02,P ＜ 0.01),but no statistical association was detected for plasminogen activator inhibitor type-1 (OR =1.27,95％ C10.84-1.93,P =0.26).Furthermore,two out of ten polymorphisms,each of which was investigated in a multicenter study with sample size larger than 400,also suggested a positive association with ICH.They were apolipoprotein A (OR =1.64,95％ CI 1.21-2.21,P ＜0.01) and vessel endothelial growth factor 2 (OR =3.22 ;95％ CI 1.63-6.37,P ＜ 0.01) respectively.Conclusions ε2 and ε4 carriers of apolipoprotein E,angiotensin converting enzyme I/D,methylene tetrahydrofolate reductase C677T,lower repeats of TTTTA of apolipoprotein A and vascular endothelial cell growth factor 2 rs2305948 polymorphisms are the possible genetic risk factors in Chinese.In conclusion,several genes are identified as to be susceptible to ICH in Chinese by our well defined criteria,however,the evidence for majority of studies is limited.