The study of association between genetic variants in sortilin-related receptor 1 and Alzheimer's disease / 中华老年医学杂志

ABSTRACT

Objective To investigate the association between gene polymorphism of sortilinrelated receptor 1 (SORL1) and Alzheimer' s disease by detecting a series of single nucleotide polymorphisms (SNPs).Methods The Snapshot method was used to genotypc 6 SNPs (SNP10,19,23,24,25,27) in SORL1 and the distributions of allele and genotype of the 6 SNPs were compared between AD patients and healthy control individuals.Results There were significant differences in the genotype distributions of SNP19,23,24 and 25 between AD patients and control group (all P＜0.01).Subjects with TT genotype in SNP19 had significantly lower risk for AD and was protective for AD (OR=0.089,95％CI0.011-0.718,P＜0.01).The AT genotype in SNP23 (OR＝3.826,95％CI1.388～10.544,P＜0.01),CT genotype in SNP24(OR=5.935,95％CI1.774-19.853,P＜0.01)and CT genotype in SNP25(OR=5.754,95％CI2.007-16.496,P＜0.01)had higher risks for AD.Conclusions SORL1 gene variants of SNP19,23,24 and 25 might be the important risk factors for late-onset AD.