Research progress of mesenchymal stem cell-antitumor gene complexes in cancer treatment / 肿瘤研究与临床

ABSTRACT

Mesenchymal stem cell (MSC) possesses highly self-renewal properties and potential ability of multiple differentiations.The homing and directional migration of MSC to tumors makes MSC uniquely destined as a potential anti-tumor gene carrier.MSC itself is discovered involved in remodeling the tumor microenvironment and regulating the biological behaviors of tumor cells such as invasion,proliferation and migration.Anti-tumor genes,such as tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) combine MSC to constitute a complex dually targeting tumor cells for destruction,but no damage to normal tissue.However,many questions remain to be answered and the precise mechanisms remain unclear.In this article,the current situation and prospects of the homing mechanism of MSC,the effects of MSC to tumor biological behavior and MSC-antitumor gene complex for tumor therapy are reviewed.