Effect of fresh isolated platelets combined with hemocoagulase on rehaemorrhagia after operation in the patients with cerebral hemorrhage treated with aspirin / 中国综合临床

ABSTRACT

Objective To investigate the effects of fresh isolated platelets combined with hemocoagulase on treating and preventing rehaemorrhagia after operation in the patients with cerebral hemorrhage who treated with aspirin.Methods Forty-six patients with cerebral hemorrhage who treated with aspirin were divided into combined therapy group(n =23) and simple therapy group(n =23).Eighteen patients with no aspirin treated were as control group.All patients were received the same basic treatment of small bone flap craniotomy and hemocoagulase.Moreover,patients in combined therapy group were treated with fresh isolated platelets before and after operation.The remained haematoma volume,the volume of draining,platelect aggregation rate,platelet adhesion rate,prothrombin time and activated partial thromboplastin time were measured before and after treatment respectively.Results Before treatment,the haematoma volume were(53 ± 11) ml,(51 ± 13) ml,(50 ± 15) ml in combined therapy group,basic therapy group and control group respectively,and no significant difference was found among the three groups(F =0.29,P ＞0.05).The rate of platelet aggregation and the rate of platelet adhesion in combined treatnnet group were (43.6 ± 6.2) ％ and (41.6 ± 8.5) ％,and (43.1 ± 5.0) ％,(42.7 ± 8.9) ％ in simple group,significantly lower than that in control group ((65.2 ± 6.1) ％,64.3 ±9.1) ％.F =92.93,40.93,P ＜0.05)).At 1st day after treatment,the remained haematoma volume and the volume of draining in combined therapy group were(7 ±4) ml and (301 ±21) ml,significantly lower than that in simple therapy group ((19 ± 5) ml,(413 ± 26) ml,P ＜ 0.05).While the rate of platelet aggregation (64.8 ±5.7)％ and the rate of platelet adhesion(63.3 ±6.6)％ in combined therapy group were significantly higher than that in simple therapy group ((51.6 ± 3.7) ％,(50.3 ± 7.8) ％,P ＜ 0.05).And compared to control group ((68.1 ± 5.9) ％,(67.4 ± 9.5) ％),there were no significant difference between combined therapy group and control group (P ＞ 0.05).Conclusion Fresh isolated platelets combined with hemocoagulase can improve the function of blood clotting and reduce rehaemorrhagia after operation in the patients with cerebral hemorrhage who treated with aspirin.