Progress in the research of relationship between γH2AX, ATM and DNA damage by endogenous oxidants / 基础医学与临床

ABSTRACT

This review describes the observations that constitutive ATM activation (CAA) and H2AX phosphoryla-tion (CHP) caused by endogenous oxidants in normal cells as well in tumor cell lines.This review also reported the findings on differences in CAA and CHP on the effects of several agents and growth conditions.