A Meta-analysis of efficacy and safety of sublingual immunotherapy on allergic asthma / 中华内科杂志
Chinese Journal of Internal Medicine
;
(12): 844-848, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-442089
ABSTRACT
Objective To evaluate the efficacy and safety of sublingual immunotherapy (SLIT) in patients with allergic asthma in order to provide reliable evidence for clinical application of SLIT.Methods To search published articles of randomized controlled trials (RCTs) in allergic asthma from CNKI,WANFANG,Pubmed and Medline databases.The methodological quality of trials was assessed by Jadadscale.The heterogeneity was examined by using Stata 11.0 software.Fixed effect model or random effect model was used to pool the data.The articles which could not be pooled were carried out by descriptive analysis.The Egger's and Begg's test were used to evaluate the publication bias.Results There were total 6 RCTs included in this text.Compared with control group,SLIT could significantly reduce asthma symptom scores (SMD =-0.89,95% CI-1.36--0.43,P =0.000) and asthma medication scores (SMD =-4.53,95%CI-6.97--2.08,P =0.000),but not forced expiratory volume (FEV1) of lung function (SMD =0.19,95% CI-0.02-0.41,P =0.078),neither serum sIgE levels (SMD =0.05,95% CI -0.58-0.69,P =0.870).There were no obvious adverse events reported after treatment of SLIT.No publication bias were indicated by Egger's and Begg's tests.Conclusion SLIT significantly reduces asthma symptom scores and medication scores,suggesting that SLIT is a safe and effective approach of immunotherapy.However,it still needs more highly qualified studies of RCTs to prove.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Idioma:
Chino
Revista:
Chinese Journal of Internal Medicine
Año:
2013
Tipo del documento:
Artículo
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