Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
Psychiatry Investigation
;
: 876-878, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-44333
ABSTRACT
In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p < 0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastorno Autístico
/
Variación Genética
/
Haplotipos
/
Regiones Promotoras Genéticas
/
Predisposición Genética a la Enfermedad
/
Semaforinas
/
Trastorno del Espectro Autista
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Psychiatry Investigation
Año:
2017
Tipo del documento:
Artículo
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