Changes of anti-thyroid drug on bone mineral density and bone turnover parameters in patients with Graves disease / 中华全科医师杂志

ABSTRACT

To explore the changes of anti-thyroid drug (ATD) on bone mineral density and bone turnover parameters in patients with Graves disease (GD).Compared with the healthy controls during the same period,the serum levels of alkaline phosphatase (AKP) and bone gla protein (BGP) in GD patients significantly increased at pre-treatment and after normal thyroid by treatment (P ＜ 0.05,P ＜ 0.01).AKP and BGP of GD patients reduced to normal level at Month 6 after normal thyroid (P ＞ 0.05) ; BMD significantly decreased at pre-treatment and Month 12 after normal thyroid (P ＜ 0.05,P ＜ 0.01).And it dropped to normal level at Month 18 (P ＞ 0.05).GD could affect bone metabolism and thyroid hormone might accelerate bone metabolism directly.