Clinical significance of BRCA1 and Ki-67 expression in breast cancer / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 1-5, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-443520
ABSTRACT
Objective To investigate the clinicopathologic features and prognostic significance of BRCA1 and Ki-67 expression in breast cancer.Methods The expression levels of BRCA1 and Ki-67 were assayed by immunohistochemistry in 194 cases of breast cancer tissues.The correlations of BRCA1 and Ki-67 expression with patients' clinicopathologic features were also analysed.Results Low expression of BRCA1 was detected in the lymph node metastasis group,ER/PR negative group,and HER-2 positive group in 194 patients with breast cancer (P < 0.05),as well as in the triple negative breast cancer (TNBC) group compared to non-TNBC group (P <0.05).High expression of Ki-67 was detected in patients with higher histological grade,negative ER/PR,and positive HER-2 (P < 0.05).Furthermore,negative correlation was found between the expression of BRCA1 and Ki-67 (P < 0.05).The combination of low expression of BRCAl and high expression of Ki-67 was mostly found in the patients with postmenopausal,lower histological grade,lymph node metastasis,negative ER/PR and positive HER-2 (P < 0.05).However,there was no significant difference between TNBC and non-TNBC.Conclusion Joint detection of BRCA1 and Ki-67 might play an important role in predicting clinical outcomes of breast cancer,especially BRCA1 may be one of prognostic factors in TNBC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Cancer Research and Clinic
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS