Correlation between the estrogen replacement therapy and the prevalence of female with Alzheimer's dis-ease:a meta-analysis / 中国神经精神疾病杂志
Chinese Journal of Nervous and Mental Diseases
; (12): 7-11, 2014.
Article
en Zh
| WPRIM
| ID: wpr-443845
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the relationship between estrogen replacement therapy and female patients with Alzheimer's risk. Methods We searched the PubMed, Springer, CBM, CNKI, VIP database for studies on the es-trogen replacement therapy and women with Alzheimer's disease, retrieval time from database to 2012 December. We evaluated the methodological quality of the included studies, used RevMan 5.0 software to analyze the extracted data. Results We found seven case-control studies which included 1392 patients and 2719 controls. The meta analysis re-sults show that the proportion of estrogen replacement therapy in AD group is significantly lower than that of the con-trol group, the difference has statistically significant [OR=0.68, 95%CI(0.50,0.90), P=0.01]. Conclusions estrogen re-placement therapy has effects on female patients with Alzheimer's disease, and is a protective factor.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Nervous and Mental Diseases
Año:
2014
Tipo del documento:
Article