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Moderate hypofractionated image-guided thoracic radiotherapy for locally advanced node-positive non-small cell lung cancer patients with very limited lung function: a case report
Radiation Oncology Journal ; : 180-184, 2017.
Artículo en Inglés | WPRIM | ID: wpr-44434
ABSTRACT
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/ CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function (FEV1 ≤ 1 L).
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuidados Paliativos / Pronóstico / Radioterapia / Carcinoma de Pulmón de Células no Pequeñas / Carga Tumoral / Electrones / Tomografía Computarizada Cuatridimensional / Quimioterapia de Inducción / Radioterapia Guiada por Imagen / Pulmón Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuidados Paliativos / Pronóstico / Radioterapia / Carcinoma de Pulmón de Células no Pequeñas / Carga Tumoral / Electrones / Tomografía Computarizada Cuatridimensional / Quimioterapia de Inducción / Radioterapia Guiada por Imagen / Pulmón Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2017 Tipo del documento: Artículo