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Effects of Dezocine extended analgesia on serum interleukin-6 and substance P in laparoscopic surgery in patients / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 58-60, 2014.
Artículo en Chino | WPRIM | ID: wpr-445056
ABSTRACT
Objective To explore dezocine preemptive analgesia in laparoscopic operation on serum interleukin-6(IL-6) and substance P.Methods 82 cases of laparoscopic operation were randomly divided into two groups,41 cases in the observation group,41 cases in the control group.Observation group was treated with routine anesthesia and analgesia with dezocine,the control group with routine anesthesia.Using visual analogue score (VAS) of pain scores,measured in the two groups of serum IL-6 and P material.Results The observation group after 2h,12h,24h VAS scores were (1.02 ±0.42),(2.19 ±0.87),(1.69 ±0.96) points,which were less than the control group (1.39 ±0.77)%,(3.08 ± 1.15)%,(2.27 ± 1.21)points (t =5.536 2,2.064 4,3.756 4,all P <0.05).The observation group before and after operation,serum IL-6,P material were (117.4 ± 17.2) mg/L,(204.4 ± 23.6) mg/L,(4.21 ± 0.96) mg/L,(4.33 ± 1.03) mg/L,the control group were (115.3 ± 14.7) mg/L,(276.5 ± 29.1) mg/L,(4.19 ± 0.94) mg/L,(6.92 ± 1.37) mg/L,two groups of postoperative serum IL-6,substance P (t =3.754 4,7.643 0,all P < 0.05).Increased significantly,compared with the control group,the patients in the observation group the extent of small elevated(t =3.7544,7.6430,all P < 0.05).Conclusion Dezocine extended analgesia in patients undergoing laparoscopic surgery can significantly reduce serum IL-6 and substance P expression.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Primary Medicine and Pharmacy Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Primary Medicine and Pharmacy Año: 2014 Tipo del documento: Artículo