The comparative study of population characteristics and clinical performance differences in the liver cirrhosis with different causes of disease / 中国综合临床

ABSTRACT

Objective To investigate the differences of the characteristic and syndrome of patients with alcoholic cirrhosis(AC) and viral cirrhosis(VC).Methods Seventy patients with AC and 300 patients with VC in the Binzhou People's Hospital were selected as our subjects.The information including gender,age,disease history,chnical syndrome were collected.Meanwhile,the levels of Aspartate aminotransferase/alanine aminotransferase (AST/ALT),γ-glutamyl transferase (γ-GT),alkaline phosphatase (ALP) and total bilirubin (TBil) in serum were measured.Results The proportion of males in the AC group was 91.43％ (64/70),significantly higher than that of VC group(64％ (192/300),x2 =15.76,P =0.003)).The age,disease periods in AC group were (50.13 ± 12.35) years old and (2.09 ± 0.67) years,lower than the VC group ((58.66 ± 7.45) yearsold,t =3.97,P =0.042 ; (4.56 ± 1.14) years,t =5.22,P =0.034).There was no significant difference regarding of liver function index (P ＞ 0.05).The rate of nasal carp (18.57％),gum bleeding (27.14％),liver palms(64.29％),spider(45.71％) in the AC group were significantly higher than the VC group (6.33％,15.00％,47.00％,29.67％ respectively,P =0.017,0.036,0.025,0.016 respectively).The ratio of splenomegaly and esophageal varices were (81.43％) and (65.71％) in AC group,significantly lower than VC group (90.33％,86.00％ respectively,P =0.037,0.011 respectively).The cirrhosis laboratory parameters results showed AST/ALT ratio (1.97 ± 0.45),gamma-GT ((152.33 ± 23.41) U/L),ALP indicators ((232.46 ±35.16) U/L in AC group patients,which were significantly higher in the VC group(1.00± 0.22,(45.89 ± 11.23) U/L and (102.23 ± 21.78) U/L,P =0.035,0.011,0.007 respectively).Conclusion There are difference in term of characteristic,manifestations and the testing laboratory indicators between alcoholic cirrhosis and viral cirrhosis.