Salicylic acid derivatives as simplified and novel GK small molecule activators / 药学学报
Acta Pharmaceutica Sinica
;
(12): 514-20, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-445611
ABSTRACT
Glucokinase (GK) is a new target for the treatment of type II diabetes mellitus (T2DM). In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1). Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
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