Hyperventilation delays clinical induction of desflurane
Anesthesia and Pain Medicine
;
: 216-221, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-44612
ABSTRACT
BACKGROUND:
Ventilation is a major determinant of the alveolar concentration of inhaled anesthetics. Hyperventilation accelerates the equilibration of anesthetic in the lungs, but decelerates it in the brain. We evaluated this phenomenon for desflurane.METHODS:
Twenty healthy subjects were enrolled after IRB approval. End-tidal concentrations of desflurane (P.DESF) were recorded during 10 minutes of mask induction with 8% desflurane. P.DESF was modeled with time and end-tidal concentrations of CO2 (P.ETCO2) using a two-exponential pharmacokinetic equation. Bispectral index (BIS) values were also measured to find out the component reflecting the cerebral concentration of desflurane.RESULTS:
During induction, the rise of P.DESF could be separated into two components early and late rises. Individual BIS values showed a higher correlation with the late component of P.DESF (P = 0.000). P.ETCO2 had two different effects on the rise of P.DESF.CONCLUSIONS:
Hyperventilation hastened the early rise and delayed the late rise of P.DESF (P = 0.00, P = 0.00). Hyperventilation should be avoided to obtain rapid anesthesia induction with desflurane.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ventilación
/
Encéfalo
/
Dinámicas no Lineales
/
Comités de Ética en Investigación
/
Hiperventilación
/
Isoflurano
/
Anestesia
/
Anestesia por Inhalación
/
Anestésicos
/
Pulmón
Idioma:
Coreano
Revista:
Anesthesia and Pain Medicine
Año:
2010
Tipo del documento:
Artículo
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