The change of serum IL-17 and Dectin-1 in non-neutropenic patients with invasive pulmonary aspergillosis / 中国感染与化疗杂志
Chinese Journal of Infection and Chemotherapy
;
(6): 240-244, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-446532
ABSTRACT
Objective To explore the changing levels of serumIL-17 and Dectin-1 and their implication in non-neutropenic pa-tients with invasive pulmonary aspergillosis (IPA).Methods The clinical data were reviewed for 23 non-neutropenic patients with clinical diagnosis of IPA (IPA group),31 patients with clinical diagnosis of pneumonia (pneumonia group)and 51 healthy subjects(control group).The peripheral serum was collected to analyze IL-17 level by ELISA.Serum Dectin-1 level was also determined at the same time.Serum G test,GM test,WBC and CRP level were also assayed for the patients in IPA group.Pa-tient outcome was followed up and analyzed in terms of serum IL-17.Results The serum IL-17 level of the patients in IPA group was significantly higher than that in the control group (P 0.05).The serum Dectin-1 level in IPA group was significantly higher than that in the control group (P 0.05 ). Conclusions Dectin-1 may be produced and Th17 cell immunity activated in response to Aspergillus fumigatus in-fection in non-neutropenic patients.And,serum Dectin-1 level is correlated with Th17 response.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Infection and Chemotherapy
Año:
2014
Tipo del documento:
Artículo
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