The Clinical Effect and Influence on cardiac function of losartan joint tartrate metoprolol on heart function in patients with coronary heart disease(CHD) and chronic heart failure(CHF) / 中国基层医药

ABSTRACT

Objective To explore the clinical effect and influence on cardiac function of losartan joint tar-trate metoprolol on heart function in patients with coronary heart disease ( CHD ) and chronic heart failure ( CHF ) . Methods 76 patients were randomly divided into two groups with double blind method ,control group adopted tartrate metoprolol treatment ,observation group on the basis of the losartan treatment ,compared two groups of cardiac function changes and clinical curative effect .Results After treatment,changes of DP/dtmax,DP/dtmax,LVEDP were greater than those of the control group ,the difference was statistically significant ( t=9.141,75.458,9.141,75.458,all P<0.05);compared with control group , the differences in LDH, SOD, NO were statistically significant ( t =6.951, 15.694,6.951,P<0.05);Observation group effectiveness was 89.47%,control group effectiveness was 78.95%, the difference in efficient between the two groups have statistical significance (Ridit=16.951,P=16.951);the rate for incidence of major adverse cardiovascular events in observation group was 7.89%;control group was 10.53%, there was no statistically significant difference in two groups (χ2 =0.695,P=0.695).Conclusion Curative effect of losartan with tartrate metoprolol treatment of coronary heart disease (CHD) is distinct,combination may be considered in clinical application and can improve cardiac function in patients adjusting the nerve -endocrine disorder from differ-ent mechanism .