Research progress of neoadjuvant radiotherapy and prediction of radiosensitivity for rectal cancer / 肿瘤研究与临床

ABSTRACT

Neoadjuvant radiotherapy could decrease the local recurrence rate,increase the probability of the anal sphincter preservation,improve survival rate and the quality of patients' lives.For stage Ⅲpatients with rectal cancer,the recurrence rate is higher in short-course radiotherapy compared with conventionally radiotherapy.Molecular markers combined with gene technology can be used as radiosensitivity indicators.Conventional radiotherapy has a definite effect and radiotherapy combined with chemotherapy has better efficacy.The extensive researches of diverse molecular markers,gene expression profiling and gene chips for rectal cancer provide the basis of personalized treatment.