Influence of Cushing′s syndrome on metabolic indexes / 心血管康复医学杂志

ABSTRACT

Objective:To compare influence of Cushing's syndrome and essential hypertension (EH)on metabolic in-dexes.Methods:A total of 22 pathologically confirmed patients With Cushing's syndrome Were regarded as Cushing group and 22 EH patients,Who admitted in the same period With matched age,gender,nationality,body mass index (BMI)and mean blood pressure level for Cushing group,Were enrolled as EH group.Fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG),fasting insulin (FINS),2h postprandial insulin (2hINS),homeostasis mod-el-insulin resistance index (HOMA-IR),total cholesterol (TC),triglyceride (TG)and high density lipoprotein cho-lesterol (HDL-C)etc.Were compared betWeen tWo groups,and they Were statistically analyzed.Results:Com-pared With EH group,there Were significant increase in FBG [(4.75±0.44)mmol/L vs.(6.31±0.51)mmol/L], FINS [(13.04±2.68)mU/L vs.(29.05±2.92)mU/L],2hPBG [(7.32±0.82)mmol/L vs.(8.96±1.14)mmol/L],2hINS [(37.66±9.21)mU/L vs.(104.45±23.14)mU/L],HOMA-IR [(2.57±0.44)vs.(7.96±0.56)], TC [(4.15±0.93)mmol/L vs.(5.17±1.35)mmol/L]and TG [(1.44±0.87)mmol/L vs.(2.24±1.25)mmol/L]in Cushing group,P<0.05 or<0.01.Conclusion:Compared With essential hypertension,there are more meta-bolic changes and more obvious insulin resistance in Cushing's syndrome.