Effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12): 451-453, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-450276
ABSTRACT
Objective To evaluate the effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice.Methods Thirty-six healthy male Kunming mice,aged 40 days,weighing 25-30 g,were randomly assigned into 3 groups (n =12 each)control group (group C),0.1% sevoflurane group (group L) and 0.5 % sevoflurane group (group H).The mice inhaled 0.1% (group L) or 0.5% sevoflurane (group H) between 1800-600 (the next day) every night for 30 days.Water maze test was performed at 27-30 days of inhalation.Blood samples were collected from the left ventricle for blood gas analysis and for determination of blood electrolytes.Results There was no significant difference in swimming time in Water maze test,number of errors and blood gas analysis and blood electrolytes.Conclusion Chronic exposure to subanesthetic concentrations of sevoflurane has no significant effects on memory function and homeostasis of mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Anesthesiology
Año:
2014
Tipo del documento:
Artículo
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