MicroRNA-145 in phenotypic switch of vascular smooth muscle cells / 国际儿科学杂志

ABSTRACT

In recent years,miR-145 is frequently reported as a key regulator of the phenotypic switch in vascular smooth muscle cells(VSMC),while the switch is the common pathological progress in many kinds of vascular diseases.Kidney is rich of vessels,and the regular function of its vessels has significance in the integral function of kidney.But,there is no article discussing about the relationship between miR-145 and kidney until now.This paper mainly discusses the possible mechanism of miR-145 in VSMC and present feasible experimental methods in a bid to provide a new perspective on kidney and related matters.