Childhood asthma and intestinal flora / 国际儿科学杂志

ABSTRACT

The increasing trend of incidence rate in children with allergic diseases has drawn increasingly attention,especially in children with bronchial asthma,which may affect children's life quality.The hygiene hypothesis indicates that early microbial contact and stimulation can affect the development of body immune system,lack of early microbial stimulation results in aberrant immune responses to innocuous antigens later in life.The distribution of intestinal flora in the body between children with allergic diseases and healthy children are different,indicating that the occurrence of allergic diseases is associated with intestinal flora.The abnormal number or function of regulatory T cell may be the key mechanism of allergic diseases.Although the exact mechanism is not yet fully understood,more and more researches are underway.Meanwhile,the positive effect of probiotics has been showed in the prevention and treatment of asthma and other allergic diseases cannot be ignored.Studies on allergic diseases and intestinal flora may provide a new way for their prevention and control.