Efficacy of penehyclidine hydrochloride for prevention of postoperative pulmonary complications in patients undergoing brain glioma resection / 中国医师进修杂志

ABSTRACT

Objective To evaluate the efficacy of penehyclidine hydrochloride for prevention of postoperative pulmonary complications (PPC) in patients undergoing brain glioma resection.Methods Seventy ASA class Ⅱ-Ⅲ patients,aged 30-69 years,weighing 50-80 kg,undergoing brain glioma resection,were divided into 2 groups by random digits table method:control group (group C,35 patients) and penehyclidine hydrochloride group (group W,35 patients).The patients in two groups were given the same methods of anesthesia induced and maintain.The patients in group W were given penehyclidine hydrochloride[20 μ g/kg(2 ml)] before anesthesia induced 30 min,meanwhile the patients in group C were given equal volume of saline.The occurrence of PPC was recorded within 72 h after operation and compared between two groups.Results The incidence of PPC in group W was significantly lower than that in group C [11.4％ (4/35) vs.28.6％ (10/35)] (P ＜ 0.05).Conclusion Intramuscular of penehyclidine hydrochloride 20 μ g/kg before operation can prevent the occurrence of PPC in patients undergoing brain glioma resection.