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Comparative Cognitive Effects of Levo-Dopa Plus Carbidopa and Dopamine Agonist as an Initial Therapy of Parkinson's Disease
Journal of the Korean Neurological Association ; : 341-346, 2008.
Artículo en Coreano | WPRIM | ID: wpr-45130
ABSTRACT

BACKGROUND:

Cognitive impairments are common in patients with Parkinson's disease (PD). However little is known about the cognitive effects of dopaminergic therapy.

METHODS:

The study was a single-blind prospective study of 21 patients with PD. Each patient had received either levodopa (Sinemet(R), n=8) or dopamine agonist (Requip(R), n=13) during 24 consecutive weeks. Neuropsychological battery, including Korean version of Alzheimer's Disease Assessment Scale(R) cognitive subscale (ADAS-Cog) and frontal-executive function part of SNSB (Seoul Neuropsychological Screening Battery), were performed two times, before and after the 24 weeks of management. Patients also received quantitative ratings of motor symptom severity and functional status using Unified Parkinson's Disease Rating Scale (UPDRS) before and after the dopaminergic therapy.

RESULTS:

After six months of treatment, motor scale improved in both groups (p0.05). In ADAS-Cog testing, Requip(R) group improved at more categories than Sinemet(R) group but without statistical difference (p>0.05). The results of frontal-executive function test did not differ between the groups, either.

CONCLUSIONS:

Our study does not provide an evidence that dopaminergic treatment improves cognitive functions in Parkinson's disease. Furthermore, we found no significant difference in the effect on cognition between the two tested drugs and no difference in the results of the above-listed neuropsychological tests between the first and the last visits.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Carbidopa / Dopamina / Levodopa / Tamizaje Masivo / Estudios Prospectivos / Cognición / Agonistas de Dopamina / Enfermedad de Alzheimer / Pruebas Neuropsicológicas Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional / Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Carbidopa / Dopamina / Levodopa / Tamizaje Masivo / Estudios Prospectivos / Cognición / Agonistas de Dopamina / Enfermedad de Alzheimer / Pruebas Neuropsicológicas Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional / Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2008 Tipo del documento: Artículo