FasL-Fas system and cerebral ischemia / 国际脑血管病杂志

ABSTRACT

Fas ligand (FasL) is critical for maintaining immune privilege status of central nervous system in physiological conditions.FasL binds Fas via extrinsic pathway mediated ischemic penumbra neuronal apoptosis after the onset of cerebral ischemia.In addition,FasL is involved in the regulation of T lymphocyte subsets by inducing the expression of inflammatory cytokines and chemokines,promoting intracerebral microglia activation and peripheral neutrophil infiltration,and thus aggravating immune inflammatory response after stroke.FasL-Fas system has a certain role for promoting the recovery of neural function during the convalescence of ischemic stroke.Taking FasL-Fas system as a target,it may become a new way for brain protection treatment of ischemic stroke.