Interleukin-8 and cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 450-453, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-451419
ABSTRACT
Immuno-inflammation is one of the main pathophysiological mechanisms of ischemic brain injury,of which chemokines and its receptors widely participate in the occurrence and development processes of ischemic brain injury.Interleukin-8 (IL-8) and its receptors participate in the activation and chemotaxis of neutrophils into brain tissue,and may further aggravate cerebral ischemia-reperfusion injury.At present,therapeutic drugs for IL-8 are mainly CXC chemokine receptor 2 antagonists,including narrow and broad-spectrum chemokine antagonists.This article reviews the advances in research on the pathological mechanism and targeting treatment of IL-8 in ischemic brain injury.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Cerebrovascular Diseases
Año:
2014
Tipo del documento:
Artículo
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