Usefulness of FEF25-75% in Methacholine Bronchial Provocation Test in Children with Asthma / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 408-414, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-45241
ABSTRACT
PURPOSE:
Although asthma is generally understood as a disease of the the small airways, FEF25-75%, an index representing peripheral small airways, is a appropriately used in the diagnosis of asthma. The objectives of this study are to assess the usefulness of FEF25-75% in children with asthma for clinical application.METHODS:
Five hundred sixty two 5- to 15-year-old children with symptoms suggestive of asthma were enrolled. Methacholine bronchial provocation tests were performed and the children were divided into two groups according to their test results.RESULTS:
Forced expiratory flow between 25-75 percent of vital capacity (FEF25-75%) was significantly lower in asthma group (P< 0.001). A 25 percent fall of FEF25-75% of percentage predicted value was correlated with PC20FEV1 (provacation concentration of methacholine required to reduce FEV1 by 20 percent) (r=0.601, P< 0.001). The sensitivity of PC25FEF25-75% (provocation concentration of methacholine required to reduce FEF25-75% by 25 percent) was 94.11 percent when PC20FEV1 was a point of reference. Youden's index was 0.64.CONCLUSION:
FEF25-75% is an useful and sensitive index that predicts the presence or absence and the degree of bronchial hyperresponsiveness and PC25FEF25-75% should be brought into clinical application in asthmatic children.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Pruebas de Provocación Bronquial
/
Capacidad Vital
/
Cloruro de Metacolina
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Año:
2005
Tipo del documento:
Artículo
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