Effects of depression on C-reactive protein and low-density lipoprotein levels in patients with coronary artery disease / 中国医师杂志

ABSTRACT

Objective To investigate effects of depression on C-reactive protein ( CRP) and low density lipoprotein ( LDL) levels in patients with coronary artery disease .Methods Eighty coronary heart disease patients with and without depression and 20 coronary heart disease-free cases were selected , CRP and LDL levels were measured and compared among three groups .The correlation of depression scores with CRP and LDL were analyzed .Results Depression self rating scale ( SDS) , and Hamilton Depression Scale ( HAMD) scores of patients with coronary heart disease ( CHD)+depression were 46.22 ±3.90 , and 24.39 ±3.08 ,which were sig-nificantly higher than control group (22.46 ±6.22,10.36 ±4.22) and non-depressed CHD patients (29.36 ±5.34, and 10.30 ± 4.11 ) ( P 0.05 ) .CRP and LDL levels of patients with CHD +depression were ( 24.36 ±3.25 ) mg/L, ( 2.85 ± 1.42 ) mmol/L, which were significantly higher than control group and non-depressed CHD patients ( P <0.05 ) .CRP and LDL lev-els of non-depressed CHD patients were higher than control group ( P <0.05 ) .SDS, and HAMD scores had a positive correlation with CRP, LDL, and heart rate ( P <0.05).Conclusions CHD patients should remain optimistic relaxed state of mind to improve the treatment of coronary heart disease .