Effect of DNA oxidative damage on micronucleus frequency in peripheral blood lymphocytes / 国际检验医学杂志
International Journal of Laboratory Medicine
;
(12): 1823-1824, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-453086
ABSTRACT
Objective To study the effect of DNA damage induced by H2 O2 on the micronucleus frequency in lymphocytes. Methods Resting lymphocytes were treated with different levels of H2 O2 (10,50,100,1 000 μmol/L).1 000 μmol/L H2 O2 was added into mitogen-stimulated lymphocyte cultures at different time intervals.Then micronucleus rate was examined by the conven-tional culture method.Results There was no significant change of the micronucleus frequency in the experimental groups.Conclu-sion H2 O2 could induce lymphocyte DNA damage rapidly,but exerts no effect on the formation of micronuclei,which may be relat-ed to the type of DNA damage and rapid DNA repair.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Laboratory Medicine
Año:
2014
Tipo del documento:
Artículo
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