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Perfusion-Weighted MRI Parameters for Prediction of Early Progressive Infarction in Middle Cerebral Artery Occlusion
Journal of Korean Neurosurgical Society ; : 346-351, 2016.
Artículo en Inglés | WPRIM | ID: wpr-45416
ABSTRACT

OBJECTIVE:

Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI.

METHODS:

We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institutes of Health Stroke Scale increment ≥2 points during 24 hours despite receiving standard treatment. Regional parameter ratios, such as cerebral blood flow and volume (rCBV) ratio (ipsilateral value/contralateral value) on perfusion MRI were analyzed to investigate the association with EPI.

RESULTS:

Sixty-four patients were enrolled in total. EPI was present in 18 (28%) subjects and all EPI occurred within 3 days after hospitalization. Diabetes mellitus, rCBV ratio and regional time to peak (rTTP) ratio showed statically significant differences in both groups. Multi-variate analysis indicated that history of diabetes mellitus [odds ratio (OR), 6.13; 95% confidence interval (CI), 1.55-24.24] and a low rCBV ratio (rCBV, <0.85; OR, 6.57; 95% CI, 1.4-30.27) was significantly correlated with EPI.

CONCLUSION:

The incidence of EPI is considerable in patients with acute MCA territory infarction caused by MCA occlusion. We suggest that rCBV ratio is a useful neuro-imaging parameter to predict EPI.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Perfusión / Imagen por Resonancia Magnética / Circulación Cerebrovascular / Incidencia / Estudios Retrospectivos / Arteria Cerebral Media / Accidente Cerebrovascular / Infarto de la Arteria Cerebral Media / Diabetes Mellitus / Hospitalización Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Journal of Korean Neurosurgical Society Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Perfusión / Imagen por Resonancia Magnética / Circulación Cerebrovascular / Incidencia / Estudios Retrospectivos / Arteria Cerebral Media / Accidente Cerebrovascular / Infarto de la Arteria Cerebral Media / Diabetes Mellitus / Hospitalización Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Journal of Korean Neurosurgical Society Año: 2016 Tipo del documento: Artículo