Evaluation of the Combination of Methylprednisolone and Tranilast after Spinal Cord Injury in Rat Models
Journal of Korean Neurosurgical Society
;
: 334-340, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-45418
ABSTRACT
OBJECTIVE:
The aim of our study was to evaluate the neuroprotective functions of the combination therapy using methylprednisolone (MP) and tranilast (TR) after spinal cord injury (SCI) in adult rats.METHODS:
Spinal cord compression injury model was achieved using Yasargil aneurysm clip. Rats were divided into control group, MP group, TR group, and combination therapy group using TR and MP. Rat models were assessed for locomotor functional recovery using Basso, Beattie, and Bresnahan (BBB) score, spinal cord water content and myeloperoxidase (MPO) activity 24 hours post SCI, haematoxylin and eosin staining and glial fibrillary acid protein (GFAP) staining at 7 and 14 days post SCI.RESULTS:
The spinal cord water content and MPO activity in the combination therapy group was significantly lower than the control group and the individual therapy groups p0.05). At 2 weeks after SCI there was a slight decrease in GFAP expression compared to the first week but the difference was not statistically significant (p>0.05), GFAP expression between the groups was not statistically significant p>0.05.CONCLUSION:
Combining MP and TR is therapeutically more effective in improving functional recovery, inhibiting inflammation and glial scar formation after acute SCI.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Espinal
/
Compresión de la Médula Espinal
/
Traumatismos de la Médula Espinal
/
Metilprednisolona
/
Agua
/
Cicatriz
/
Eosina Amarillenta-(YS)
/
Peroxidasa
/
Modelos Animales
/
Proteína Ácida Fibrilar de la Glía
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Neurosurgical Society
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS