NF-κB in neoplasms radiotherapy / 国际肿瘤学杂志

ABSTRACT

NuclearfactorκB(NF-κB)isanimportanttranscriptionfactorinmammaliancells.Asa multifunctional factor,NF-κB is involved in a variety of physiological and pathological processes such as immu-nity and inflammation .At the molecular and cellular level,NF-κB regulates initiation and progression of neo-plasms.NF-κB also plays an important role in cell proliferation and apoptosis of neoplasms.Radiotherapy is one of the most important methods in tumor treatment .In recent years,a number of studies discovered that NF-κB is critical in the development of resistance of tumor cells to radiotherapy,which results in poor progno-sis.We can use NF-κB as a biomarker in predicting outcomes of anticancer treatment or as prognostic indicators in patients who are with tumors.So we can find different potential inhibitors aimed at NF-κB and its signal pathway in order to improve the efficacy of radiotherapy.In the present study,the correlation of NF-κB mole-cules with radiotherapy of neoplasms is reviewed.