Comparison of two asthma models in rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1175-1178, 2014.
Article
en Zh
| WPRIM
| ID: wpr-454299
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WPRO
ABSTRACT
Aim Toestablishanexcellentratasthmamodel from using OVA+pertussis sensitized, OVA sensitized and per-tussissensitizedrats.Methods Thethreemethodswereusedto sensitize rats;methacholine bronchial provocation tests were per-formed to determine airway hyperresponsiveness;bronchoalveolar lavage fluid ( BALF) was prepared after the animals were chal-lenged by nebulized antigen. The differential white cell count in BALF was performed, and lung tissue was detected by morpho-logicalanalysis.Results AllofOVA+pertussissensitization,OVA sensitization and pertussis sensitization could deteriorate lung function, increase inflammatory cells and cause pathological change, and OVA + pertussis sensitized rat model had better effect than OVA sensitized and pertussis sensitized rat models. Conclusion OVA+pertussissensitizationandOVAaerosolisa successful rat asthma model.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2014
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Article