Oxidative stress of mitochondrial injury mechanism and targeted antioxidant in sepsis / 国际儿科学杂志

ABSTRACT

Mitochondria is an important part of cell oxidation, but oxidative stress in sepsis as end product of inflammation will cause changes of mitochondria, leading to organ damage. In general, antioxidant defense system fights oxidative stress through the interaction and prevents mitochondrial injury. Oxidative stress plays a important role in organ dysfunction. Studies have found that the targeted therapies for mitochondrial antioxidants may be a new strategy of multiple organ failure caused by sepsis. This review aims to summarize researches on oxidative stress of mitochondrial injury mechanism and targeted antioxidants in sepsis .