Progress in mechanism of acetaminophen-induced hepatotoxicity and its protective strategies / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 618-624, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-455039
ABSTRACT
Acetaminophen(APAP)is the most wideIy-used anaIgesic drug cIinicaIIy. It is aIso the most risky agent for hepatotoxicity. It has been wideIy used as a modeI drug to study mechanisms of chemicaI-induced Iiver injury and to test the hepatoprotective potentiaI of chemicaIs. This review summa-rized the intraceIIuIar events of acetaminophen-induced hepatotoxicity,incIuding metaboIic activation, ceIIuIar damage,c-Hun N-terminaI kinase pathway,and modified metaboIism function,and additionaIIy focused on the roIe of infIammatory factors and ceIIs in APAP hepatotoxicity,as weII as protection strate-gies of chemicaIs and naturaI products.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS