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Amlodipine inhibits cardiomyocyte remodeling by interfering ANP secretion / 实用医学杂志
The Journal of Practical Medicine ; (24): 2360-2363, 2014.
Artículo en Chino | WPRIM | ID: wpr-455205
ABSTRACT
Objective To verify the dynamic changes of ANP during the diastolic heart failure and the protective effect of amlodipine. Methods Male SD rats underwent the abdominal aorta ligation. Four weeks after Surgery, 40 rats were divided into 4 groups hypertension model group (group B), low-dose group (group C), mid-dose group (group D), high-dose group (group E). Another 10 healthy male SD rats were used as sham group (group A). During the experiment, different drugs were gavaged to different groups and the normal saline was used for control group. Results After 12 weeks, ANP levels increased in group B much more than in group A, while lower in group C(P 0.05); HW/BW and LW/BW decreased in group B than in group A, while higher in group C than in group B (P 0.05). Conclusion ANP level gradually increased accompanying with the aggravation of heart failure, which is related with the dose of the drug within limits. Amlodipine can inhibit cardiomyocyte remodeling by interfering ANP secretion.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: The Journal of Practical Medicine Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: The Journal of Practical Medicine Año: 2014 Tipo del documento: Artículo