Amplitude of low frequency fluctuation in first-episode depression and its relationship with the separate symptom clusters: a resting-state fMRI study / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
;
(12): 673-675, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-455541
ABSTRACT
Objective To explore the relationship between energy feature of the spontaneous neural activity and separate symptom clusters in first-episode depression.Methods 22 first-episode depression patients and 26 age-,gender-matched healthy controls were scanned with 3.0 T MRI Scanner.The t-test was employed to compare the difference of amplitude of low frequency fluctuation (ALFF) between the two groups,and the correlation analyses were conducted between ALFF of brain regions with significant difference and the severity of depressive symptoms clusters.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right middle frontal gyrus (9,45,-6; K =18) and the bilateral fusiform gyrus (-34,-19,-12; K =37 and 30,-33,-18 ; K =31,respectively),and decreased ALFF in the left precuneus (0,-72,42; K =19) (P<0.05,corrected by Alphasim).The ALFF of the the right middle frontal gyrus,the right fusiform gyrus,and the left precuneus were negative correlated with the scores of weight factor,retardation factor and sleep disturbance factor (r=-0.494,P=0.019; r=-0.486,P=0.022 and r=-0.484,P=0.023,respectively).Conclusion Abnormal energy feature of the spontaneous neural activity may be associated with severity of specific depressive symptoms clusters in first-episode depression patients during resting-state.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Behavioral Medicine and Brain Science
Año:
2014
Tipo del documento:
Artículo
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