Progress on oral Helicobacter pylori infection and its diagnostic techniques / 中华临床感染病杂志

ABSTRACT

Helicobacter pylori (Hp) is of high prevalence and can cause lifelong infection.Hp can parasite in oral cavity,which may be not only an important cause of recurrent gastrointestinal diseases,but also affect Hp eradication in stomach.Bacterial culture,rapid urease test (RUT) and polymerase chain reaction (PCR) have been widely used in diagnosis of gastrointestinal Hp infections.While due to the difference of microbial environments in oral cavity and in stomach,there exit big disparities when they are used to detect Hp in oral cavity.Saliva Hp urease antigen detection method (HPS) is a graphic immune chromogenic assay.Hp salivary culture with HPS test can help to confirm the existence of Hp in oral cavity,so as to improve Hp eradication rate through concurrent treatment of gastrointestinal and oral Hp infections.The status of oral Hp infection,its correlation with gastric Hp infection,and new techniques of oral Hp detection and culture are reviewed in this article.