Bioavailability comparison between ligusticum wallichii microemulsion and decoction in rabbits / 国际中医中药杂志

ABSTRACT

Objective To compare the difference in bioavailability of ligusticum wallichii microemulsion and decoction by detecting the concentration of Ferulic acid in rabbit plasma. Methods RP-HPLC was used to detect the concentration of Ferulic acid in rabbits plasma at different times, and software 3p87 was used to analyze the pharmacokinetics parameter. Results The pharmacokinetics parameters of ligusticum wallichii microemulsion and decoction were as follows AUC0-9=2 123.6 μg/(ml?min), Cmax=5.086 μg/ml, Tpeak=56.26 min for microemulsion;DecoctionAUC0-9=878.35 μg/(ml?min), Cmax=2.427μg/ml, Tpeak=128.86 min for decoction, F(%)=241.77. Conclusion Microemulsion of ligusticum wallichii has a higher biological availability and shorter peak time than decoction.