Effect of Losartan on Myocardial Remodeling in Myocardial Infarction Rats’Model / 中国循环杂志
Chinese Circulation Journal
; (12): 629-633, 2014.
Article
en Zh
| WPRIM
| ID: wpr-456368
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WPRO
ABSTRACT
Objective: To investigate the effect of losartan on angiotensin II (Ang II) expression and myocardial remodeling in myocardial infarction (MI) rats’ model. Methods: A total of 32 SD male rats were divided into 4 groups, Sham operation group, MI group, MI with losartan 10mg/(kg·d) group and MI with losartan 20mg/(kg·d). n=8 in each group. MI model was established and the electrocardiogram changes before and after MI were recorded, hemodynamic indexes were detected at 4 weeks after MI, pathological changes of myocardial tissue were examined by HE staining. The myocardial mRNA and protein expressions of ACE2 and Ang II were detected by RT-PCR and Western Blot analysis. Results: Compared with Sham operation group, MI group showed increased LVMI and decreased LVEF P Conclusion: Losartan could increase ACE2 expression and therefore, inhibit Ang II expression and improve the ventricular remodeling in MI rats’ model.
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WPRIM
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Zh
Revista:
Chinese Circulation Journal
Año:
2014
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Article