Design and synthesis of photoaffinity biotin labelled 2'-O-propargyl-guanosine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 59-63, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-457212
ABSTRACT
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA.
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2015
Tipo del documento:
Artículo
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