Study on the impact of different levels intensive glycemic control on the morphology of liver and lung in rats with sepsis / 重庆医学

ABSTRACT

Objective To investigate the changes and significance of different target blood glucose on septic liver and lung dam‐age and its morphology .The purpose of this study was to evaluate the pathological injury of liver and lung induced by higher blood glucose .Methods Forty SD rats randomly divided into sham operation group ,sepsis group ,group A (glucose was controlled at 4 .4 to 6 .1 mmol/L) ,group B (glucose was controlled at 6 .1 to 8 .3 mmol/L) and group C (glucose was controlled at 8 .3 to 10 .0 mmol/L) ,with 8 rats in each group .The liver and lung tissue were obtained 12 hours after cecal ligation and puncture .Then evalu‐ate and analyze the morphology change in liver and lung injury from different pathological scores ,including eight observation marker for liver and seven marker for lung .Results The pathological injury of liver and lung was significantly higher than sham treatment group for CLP and group A to C(P0 .05) ,but in the three blood glucose groups ,liver and lung injury progressive dis‐ease with the level of blood glucose elevating and the difference was significant(P0 .05) .For liver injury the main pathological features were hydropic and fatty degeneration ,and CLP group had significant differences with group A ,B and C(P<0 .05) .While CLP group showed a significant piecemeal necrosis for liver injury .Conclusion The injury of liver and lung injury in septic rats were gradually increased with elevated blood glucose levels ;blood glucose controlled within the normal range of liver rat model of sepsis could reduce the liver and lung injury .