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Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders
Journal of the Korean Ophthalmological Society ; : 96-103, 2002.
Artículo en Coreano | WPRIM | ID: wpr-45853
ABSTRACT

PURPOSE:

Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders.

METHODS:

Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed.

RESULTS:

Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05).

CONCLUSIONS:

VEGF plays a major role in the development of neovascularization in the various retinal disorders.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Retinaldehído / Desprendimiento de Retina / Ensayo de Inmunoadsorción Enzimática / Vitreorretinopatía Proliferativa / Factor A de Crecimiento Endotelial Vascular / Inductores de la Angiogénesis / Cirugía Vitreorretiniana / Hemorragia / Fotocoagulación Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Retinaldehído / Desprendimiento de Retina / Ensayo de Inmunoadsorción Enzimática / Vitreorretinopatía Proliferativa / Factor A de Crecimiento Endotelial Vascular / Inductores de la Angiogénesis / Cirugía Vitreorretiniana / Hemorragia / Fotocoagulación Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Año: 2002 Tipo del documento: Artículo