Significance of serum procalcitonin for the differential diagnosis and the use of antibiotics in acute fever / 中国医师杂志

ABSTRACT

Objective To evaluate the clinical significance and choicing antibiotics of serum procalcitonin (PCT) in acute fe-ver.Methods To make a retrospective analysis of 170 cases of febriledisease from January 2013 to January 2014.According to clini-cal causes of fever, the cases were divided between infectious fever group and non -infected group.The infectious group was divided by bacterial(A group) and viral infectious(B) groups.The bacterial group(A group) was divided by bloodstream infectious (A1) and fo-cal infectious(A2) groups.Tests of blood routine and CRP and PCT before or used antibiotics were analyzed and compared between the different groups.Results The PCT serum concentration of bacterial infectious gloup was higher than the viral infectious group and non-infected group( P 0.05). In bacterial infectious gloup, the area under ROC of PCT was 0.950 and CRP was 0.943, if PCT≥ 0.25ng/ml was regard as the cut-ff value, the sensitivity was 91.6% and the specificity was 93.3% ; if PCT≥ 0.5ng/ml was regard as the cut-ff value, the sensitivity was 95.2% and the specificity was 77.6%.Conclusions PCT tests are helpful to identify bacterial infection in patients with infec -tious fever .The more serious the higher PCT level , the earlier using antibiotics ,it is the most in bloodstream infection.There is an important significance for choicing antibiotics by the guidance of PCT ≥ 0.25ng/ml.