Effects of Dibutyl Phthalate on Rat Sperm Production and Quality / 中国药师
China Pharmacist
;
(12): 2019-2021, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-458792
ABSTRACT
Objective:
To evaluate the effects of dibutyl phthalate on rat sperm production and quality.Methods:
Totally 150 male rats were randomly divided into the low dose group (50 mg·kg-1), the middle dose group (200 mg·kg-1), the high dose group (1 000 mg·kg-1 ) , the blank control group and the solvent control group ( peanut oil as the control) with 30 ones in each. After continu-ous administration for every 30 days, 10 rats from each group were anatomized, the weight of testes and epididymides were determined, and one side of epididymis was used to carry out the sperm analysis including counting, survival rate and morphology.Results:
After intragastric administration for 90 days, the sperm count and survival rate, the weight of testis and epididymis and organ coefficient in the middle dose group and high dose group were decreased significantly(P<0. 05 or 0. 01).Conclusion:
The long-term administration of dibutyl phthalate at high dose exhibits notable toxicity on rat reproductive function.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2014
Tipo del documento:
Artículo
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