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Expression of p53, CD44v6 and VEGF in Gastric Adenocarcinomas
Journal of the Korean Gastric Cancer Association ; : 10-16, 2001.
Artículo en Coreano | WPRIM | ID: wpr-45895
ABSTRACT

PURPOSE:

The p53 protein is a tumor supressor gene, and its mutation is associated with biologic aggressiveness. CD44v6, one of the CD44 family, is a cell surface glycoprotein that plays a role in cancer invasion and metastasis. Vascular endothelial growth factor (VEGF) is another recently identified growth factor with significant angiogenic properties. The purpose of this study was to investigate p53, CD44v6, and VEGF expressions to determine whether degree of expression was related to pathological parameters such as Lauren's classification, depth of invasion, and lymph node metastasis. MATENRIALS AND

METHODS:

Immunohistochemical stains of p53, CD44v6, and VEGF in formalin-fixed paraffin-embedded tissue sections of 125 gastric adenocarcinomas were done.

RESULTS:

The overall expression rates of p53, CD44v6, and VEGF were 54.4% (68/125), 36.8% (46/125), and 48.0% (60/ 125), respectively. The p53, not CD44v6 and VEGF was higher in intestinal-type gastric carcinomas by Lauren's classification. The expressions of p53, CD44v6, and VEGF were statistically correlated with depth of tumor invasion. The expression of CD44v6 was higher in the lymph node metastatic group than in the negative group. The p53 expression was significantly associated with VEGF expression.

CONCLUSIONs:

These data suggest that the expressions of p53, CD44v6, and VEGF are biologically related to malignancy. The p53 and CD44v6 expressions are independent; however, p53 gene mutation is one of the contributing factors to VEGF expression in gastric adenocarcinoma.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Glicoproteínas de Membrana / Adenocarcinoma / Genes p53 / Clasificación / Factor A de Crecimiento Endotelial Vascular / Colorantes / Ganglios Linfáticos / Metástasis de la Neoplasia Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Gastric Cancer Association Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Glicoproteínas de Membrana / Adenocarcinoma / Genes p53 / Clasificación / Factor A de Crecimiento Endotelial Vascular / Colorantes / Ganglios Linfáticos / Metástasis de la Neoplasia Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Gastric Cancer Association Año: 2001 Tipo del documento: Artículo