Research advance in cGAS-STING pathway:a pathway unlock the anti-HIV function of immune system / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 528-532, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-459136
ABSTRACT
Stimulator of interferon genes(STING)are important adaptor proteins in innate immune-related signal pathway. The upstream protein,cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS),is cytosolic DNA sensor. Detection of cytosolic DNA,cGAS-STING pathway can be activated and subsequently activate the type Ⅰ interferon (IFN)antiviral response. Recent studies indicated that retroviruses especially HIV can activate the host innate immune system through cGAS-STING pathway and trigger robust immune response. In this review,we briefly describe the mechanism of innate immune activated by the newly discovered cGAS-STING pathway and highlight recent progress in STING agonist.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of International Pharmaceutical Research
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS