Efficacy of valsartan combined with Huangkui capsules in treatment of chronic glomerulonephritis / 中国生化药物杂志

ABSTRACT

Objective To discuss clinical curative effect and value of valsartan combined with Huangkui capsule on the chronic glomerulonephritis proteinuria.Methods 70 cases of patients with chronic glomerulonephritis proteinuria were selected in our hospital,and randomly divided into two groups,35 cases in control group with valsartan oral,80 mg per time,once per day,8 weeks as a course of treatment;35 cases in experimental group, combined with Huangkui capsule on the basis of conventional treatment orally,5 capsules per time,3 times per day,8 weeks for a period of treatment. After 8 weeks treatment,changes of serum creatinine,serum urea nitrogen,the urine protein and clinical therapeutic effect were compared before and after treatment in two groups.Results Contents of serum urea nitrogen,serum creatinine,urine protein were improved in two groups after treatment, and serum creatinine contents of experimental group (153.69 ±13.78)μmol/L was lower than that of control group (179.19 ±23.49)μmol/L,and the difference was statistically significant (P<0.05);serum urea nitrogen contents of experimental group (7.09 ±1.16)mmol/L was lower than that of control group (9.29 ±2.38)mmol/L,and the difference was statistically significant (P<0.05);urine protein contents of experimental group (0.57 ± 0.32)g/L was lower than that of control group (0.89 ±0.26)g/L,and the difference was statistically significant(P<0.05);clinical curative effect of experimental group was better than that of control group,and the difference was statistically significant(P<0.05 ).Conclusion Valsartan combined with Huangkui capsule could effectively reduce albuminuria symptomsin the treatment of patients with chronic glomerulonephritis proteinuria,which has a remarkable effect,and has a positive significance for the renal function recovery.