Risk factors for venous thromboembolism in hospitalized patients undergoing total hip or knee joint replacement at the perioperative period / 重庆医学

ABSTRACT

Objective To analyze the risk factors for venous thromboembolism(VTE) in hospitalized patients undergoing to‐tal hip arthroplasty (THA) or total knee arthroplasty (TKA) at the perioperative period .Methods One hundred and seventy‐four in hospitalized patients who was given THA or TKA from October 2012 to July 2013 were enrolled in this prospective cohort stud‐y .There are a total of 205 cases of surgery ,including 132 T HAs in 122 patients and 73 TKAs in 52 patients .All patients were given Color Doppler Ultrasonography of lower limbs to detect DVT in 3 to 5 days after operation and preoperative .Then the patients were divided into two groups ,the DVT group and the non DVT group according the Ultrasonography results .More than ten factors such as age ,gender ,hypertension in DVT formation were detected .Then their correlation was analyzed .The key influencing factors for DVT were selected .Results Forty‐three patients developed DVT after operation ,the incidence of DVT was 24 .7% .Age≥ 70 years ,rheumatoid and relatively lower PT‐INR before surgery has a statistical significance (P<0 .05);elevated plasma D‐dimer val‐ue before surgery and general anesthesia has a highly statistical significance (P<0 .01) .A preoperative plasma D‐dimer cutoff value as a diagnostic test was calculated as 764 μg/L .Conclusion Age≥70 years old ,relatively lower PT INR ,preoperative elevated plasma D‐dimer value ,rheumatoid and general anesthesia were the risk factors for DVT formation after THA or TKA .A preopera‐tive plasma D‐dimer cutoff value as a diagnostic test was obtained as 764 μg/L .