Effect of Monosialotetrahexosyl Ganglioside Sodium Injection on Spastic Cerebral Palsy / 中国康复理论与实践

ABSTRACT

Objective To observe the clinical effect of monosialotetrahexosyl ganglioside sodium injection (GM1) on spastic cerebral palsy. Methods 98 children with spastic cerebral palsy were randomly divided into control group (n=50) and treatment group (n=48). Both groups received Bobath approach, and the treatment group received GM1 in addition. They were assessed with Functional Independence Measure for Children (WeeFIM), Gross Motor Function Measure (GMFM) and Gesell Development Schedule (GDS) before and after 90 days of treatment. Results The scores of WeeFIM, all the dimensions of GMFM and the gross motor, fine motor, personal-social and adap-tion of the GDS improved in both groups after treatment (P<0.05), and improved more in the treatment group than in the control group (P<0.05). Conclusion GM1 may further improve the recovery of function for children with spastic cerebral palsy.